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A full medical screening is required before starting

However, weight loss itself, whether achieved through medication or lifestyle change, leads to reductions in both fat mass (FM) and lean mass (LM) , meaning that muscle and bone are often lost alongside fat

As such, SKO mice provide a valuable model to examine potential therapies for lipodystrophies

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Visible waistline changes typically emerge in weeks 3 to 6

Abbreviations GSH: l-glutathione ATP: adenosine triphosphoric acid -GCS: -glutamylcysteine synthetase GS: glutathione synthetase GGT: -glutamyltranspeptidase PepT: tripeptidase CD: cysteine desulfhydrase CBL: -lyase GBE: glycogen-branching enzyme l-SDs: l-serine deaminases PK: pyruvate kinase PEP: phosphoenolpyruvic acid G6P: glucose 6-phosphate F6P: fructose 6-phosphate PFK: phosphofructose kinase IPTG: isopropyl -D-1-thiogalactopyranoside DCW: dry cell weight 2-DE: two-dimensional electrophoresis TCA: trichloroacetic acid CBB: coomassie brilliant blue EMP: embden meyerhof pathway References Meister A, Anderson ME