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The Institute for Clinical and Economic Review (ICER) analysis (2025) reaffirmed that even after price drops, GLP-1s consume a large share of pharmacy budgets, though at cost-effective levels relative to benefit ( [11] )

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SGLT2is have the benefit of being oral agents, which may make them an attractive choice for prescribers and a convenient add-on treatment for patients [11]

Considering the totality of evidence from clinical trials, post-marketing reports and observational studies, alongside the generally low incidence rate of NAION, Novo Nordisk believes that the benefit-risk profile of semaglutide remains favorable, the spokesperson said.

Semaglutide is intended for the management of type 2 diabetes and weight management

When protein reaches intestinal L-cells, it triggers significantly more GLP-1 release than carbohydrates or fat