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The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]

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Nutr J 14:107 Milutinovic PS, Alcorn JF, Englert JM, Crum LT, Oury TD (2012) The receptor for advanced glycation end products is a central mediator of asthma pathogenesis

10.3390/nu13082750 51 TakayaK.SuzukiT.MotohashiH.OnoderaK.SatomiS.KenslerT

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International Journal of Molecular Sciences, 24 (3), 2370