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Dr Jarred Younger, a prominent researcher in neuroinflammation and chronic pain, has publicly stated that semaglutide does reduce chronic pain via these three pathways, but also acknowledged that all the semaglutide and microglia studies I know of are in animal models theres still another step that needs to be taken. That caveat matters enormously, and its one well come back to

Sladek, F

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On the other hand, another meta-analysis showed that GLP-1 RAs reduced the risk of CV death [Risk Ratio (RR), 0.90