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Zhuo R et al
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Reporting of limitations of observational research
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In vitro experiments showed that high glucose toxicity inhibited GLP-1 secretion by enteroendothelial cells and suppressed -catenin and TCF7L2 levels, suggesting an important role for TCF4 (TCF7L2) in glucose homeostasis and type 2 diabetes development (Shen et al., 2020
These trials have been carefully structured to evaluate various aspects of its performance, ranging from initial safety reviews to its effects on weight loss and metabolic health
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