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In women, the Ovarian-Adrenal-Thyroid (OAT) axis may become unbalanced, producing concurrent symptoms of adrenal strain, estrogen dominance, and subclinical hypothyroidism

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A few unsuccessful attempts include angiotensin-converting enzyme inhibitors, angiotensin receptor one blockers and mineralocorticoid receptor antagonists ( 2.1 Hypertension Systemic hypertension is one of the most significant comorbidities in HFpEF patients (Heidenreich et al., 2022)