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Cell 162 , 540551 (2015)

This decline may reflect a favorable shift in systemic glucose regulation and insulin sensitivity, potentially driven by enhanced micronutrient availability and modulation of gut microbial composition

In severe cases, coma or even life-threatening situations may occur

Plants and mushrooms represent rich natural reservoirs of polyphenolic compounds, where these bioactives serve important roles in ecological defense and physiological regulation

For best results, use consistently for at least 3 months.

A practical strategy includes: Starting the day with a high-fibre breakfast, such as porridge with berries and ground flaxseed Including vegetables with both lunch and dinner Choosing wholegrain varieties of bread, pasta, and rice Ensuring adequate fluid intake (6-8 glasses daily) Considering a psyllium supplement if dietary measures prove insufficient (taken with plenty of water and separated from other oral medicines by at least 2 hours) Patients should contact their GP if constipation persists despite these measures, as additional interventions may be required