Ive been on GLPs
Phase 2 trial results (48 weeks, adults with obesity): 1 mg dose: 7.2% body weight loss 4 mg dose: 12.9% body weight loss 8 mg dose: 17.3% body weight loss 12 mg dose: 24.2% body weight loss Placebo: 1.6% body weight loss Phase 3 TRIUMPH-4 results: 9 mg dose: 20.0% body weight loss (22.9 kg / 50.5 lbs) 12 mg dose: 23.7% body weight loss (27.2 kg / 60.0 lbs) Placebo: 4.6% body weight loss In a separate phase 3 analysis, retatrutide at the highest dose achieved up to 28.7% weight loss
The Solution: You can eliminate this side effect by eating smaller meals, drinking far more water, using a tongue scraper, and avoiding high-fat or sulfur-rich foods
A significant reduction in heart failure events
A single medication that addresses the reward dysregulation underlying both could simplify treatment, improve compliance (patients are motivated by visible weight loss), and reduce the sense of being pulled in multiple directions that so many patients describe
The regulatory landscape for peptide therapy continues to evolve, and patients should discuss current availability with their prescribing clinician