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One approach in creating a mitochondria-targeted AT is to bind an antioxidant molecule (e.g., SOD, thiol, vitamin E, BHT, ebselen, CoQ, or various spin traps, such as TEMPO) with a hydrocarbon chain of varying length to the phosphorus of the lipophilic compound triphenylphosphonium (TPP) such as mitoquinol (MitoQ 10

Cushings disease is another condition that can be potentially life-threatening, where you have an extremely high amount of cortisol