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Real-world data from a 2025 study in Diabetes, Obesity and Metabolism which looked at actual clinical patients rather than trial participants showed tirzepatide patients lost 5.3% of body weight over six months compared to 2.7% with semaglutide

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The extract improved body weight, lowered blood glucose, enhanced glucose and insulin tolerance, and reduced liver inflammation

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Therefore, we hypothesized that enhanced GSK-3 inhibitor delivery via FUS-induced BBB opening might further increase AD therapeutic efficacy