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Researchers noted that weight loss curves had not yet plateaued, raising the possibility that some patients may ultimately see 30% or more total body weight reduction with longer treatment

Segmental body composition tests and DXA scans often reveal SAT loss throughout the trunk and limbs

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We next exchanged the PPAR/ co-agonist Tesa with Lani, a PPAR// triple agonist that has previously been shown to ameliorate HFD-induced body weight gain 33,34 (Extended Data Fig