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That might mean things like type 2 diabetes, high blood pressure, sleep apnea or joint pain, says Dr

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1: where R max is the highest possible response of binding between the analyte and the protein, R protein is the change in response by the immobilization of the protein, M r represents the mass of the analyte or protein, and V protein represents the number of binding sites on the protein

Diabetic autonomic neuropathy: pathogenesis to pharmacological management