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Roseoflavin negatively affects FMN-specific rib operon regulators (FMN riboswitches) and flavoenzymes in bacteria, and is used together with multiple copies of rib operon genes to select their overproducing strains ( In contrast to fungi, riboflavin synthesis regulation in B

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Treatment with either lovastatin or lapaquistat appeared to reduce squalene levels even further, as they both target enzymes upstream of squalene synthesis, while conversely, NB-598 treatment produced at least a 100-fold increase in squalene levels in host cells (Fig 3D, right)

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