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The authors suggested that the sex difference in their study could be related to the sex difference seen in studies linking acne to IGF-1

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Zhu, H., Blake, S., Chan, K

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One GxE interaction hit illustrates that the fitness defect in the mitochondrial folate carrier (SLC25A32) KO cells is genetically buffered in galactose due to a lack of substrate in de novo purine biosynthesis

The result is a sustained elevation of GH and IGF-1 over several days from a single dose, dosed roughly once or twice weekly