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These approvals extend the uses of GLP-1 agonists beyond initial indications, allowing for treatments in broader patient populations, including newer indications such as cardiovascular conditions, Alzheimer's disease, obstructive sleep apnea, and obesity

It readily passes through the gut mucosal barrier and provides localized anti-inflammatory benefits to intestinal tissue

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The immunoproteasome catalytic 5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation

The goal is to understand why inflammatory signaling is elevated and whether modifiable drivers are present: visceral fat, periodontal disease, poor sleep, alcohol, insulin resistance, autoimmune activity, environmental exposure, chronic infection, or unresolved cardiometabolic risk