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Ozempic and the Risk of nAMD A recent article in JAMA Ophthamology (June 2025) suggests that vascular changes triggered by GLP-1 activity may trigger or worsen nAMD in some patients, especially those who are older, diabetic, or already at risk for macular degeneration

Collectively, these studies, ranging from molecular mechanisms to translational applications, systematically establish ferroptosis as a central link connecting metabolic disorders, oxidative stress, and structural damage to renal tubule, thereby providing a new theoretical basis and intervention targets for DKD diagnosis and therapy

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Individual biological variation in GLP-1 receptor sensitivity, metabolism, and hormonal regulation means that not everyone responds identically to the medication

doi: 10.1016/j.ijbiomac.2024.136309 16 HuangL