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Studies have highlighted the role of persistent fibrosis in aged tissues, where myofibroblasts in injured tissues of aged mice acquire a sustained senescent and apoptosisresistant phenotype, exacerbating fibrosis (Hecker et al ., 2014)

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Muscular weakness, muscle wasting, and cardiomyopathy (inflammation and damage to the heart muscle) have been observed in these patients

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McKinley S, Andre T, Gann J, Willoughby DS