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Ethics declarations Disclosure Avery Brown, Helena Sergent, Alexander Hien Vu, Helen Liu, Jason Fisher, Eduardo Somoza, Tony Mei, Jeffrey Lipman, Julia Park, Patricia Chui, John Saunders, Marina Kurian, Loic Tchokouani, George Ferzli, Christine Ren-Fielding, Manish Parikh, Megan Jenkins have no conflicts of interest or financial ties to disclose

Phase II Clinical Data Jastreboff 2023 (NEJM) reported 24.2% bodyweight reduction at 48 weeks - the largest effect size published for any metabolic peptide in clinical trials

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