No studies have validated optimal cycling schedules, and individual responses likely vary widely
10.1038/nn1884 Nat
In a 12-week study in NAFLD patients, every-other-weekly administration of up to 100 mg BFKB8488A, the highest adequately tolerated dose, reduced liver fat by about 40%, serum triglycerides and Pro-C3 by up to 25 to 30% from baseline, while increasing adiponectin by up to 40% and HDL-cholesterol by up to 20% (301)
et al., Eur J Pharmacol, 1997
The most common one is cyanocobalamin
This could mean using baseline stool analyses to guide therapy selection for example, a PD patient lacking SCFA-producers might benefit most from a butyrate-producing probiotic, whereas one with high Enterobacteriaceae might need a targeted phage or antibiotic to reduce endotoxin load