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Repurposing of FDA-Approved NSAIDs for DPP-4 Inhibition as an Alternative for Diabetes Mellitus Treatment: Computational and in Vitro Study

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Combining multiple GLP-1-based medications is not recommended due to overlapping mechanisms and increased side effect risk

Other Side Effects of GLP-1s: Dizziness Mild tachycardia (increased heart rate) Infections Headaches Indigestion (upset stomach) Temporary, mild itchiness and/or redness on your skin at the site of the injections Severe, But Rare, Side Effects of GLP-1s Pancreatitis (inflammation of the pancreas) Medullary thyroid cancer Acute (sudden) kidney injury Worsening diabetes-related retinopathy As with any prescription medication, all risks and side effects should be thoroughly discussed with your health care provider

It is a tripeptide with gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by a normal peptide linkage to a glycine

Its not currently approved to treat obesity but some doctors prescribe it off label to help people lose weight