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Some patients report that administering their GLP-1 injection in the evening, particularly after dinner, may help them manage early gastrointestinal side effects such as nausea, as they can sleep through the initial hours after injection
Another potential source of heterogeneity is the presence of vascular disease in these samples
In the late 2000s, still haunted by the fallout from drugs like rosiglitazone (brand name Avandia), linked to increased heart attack risk, the FDA laid down a blunt new rule: every new diabetes drug must prove it wont harm the heart before it ever sees pharmacy shelves
Metformin is also associated with modest weight loss or weight neutrality, making it suitable for long-term use
