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Research showed that glucagon co-agonism increased hepatic fat oxidation and thermogenesis, providing an additional fat-loss mechanism distinct from appetite suppression alone

It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue

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This placebo controlled study in 24 elderly individuals showed that a single dose of an NAD+ booster before exercise improved fatigue index, physical recovery and muscle function