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Then in May 2022, the FDA approved tirzepatide (Mounjaro) for type 2 diabetes the first GIP/GLP-1 dual agonist, hitting two incretin receptors at once and producing larger A1c and weight effects in the SURPASS program than any prior single-mechanism GLP-1
Samms RJ, Christe ME, Collins KA et al (2021) GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
To our knowledge, there have only been three published studies
USP-NF 2024
"Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain"
Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation
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