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D57 (CTR) and D254 (G), were predicted protonated, however, visual inspection did not support this prediction because of their solvent-exposed location and, therefore, were modelled in the anionic side chain form

10.1016/s1535-6108(04)00059-5 30 KanayamaG.HudsonJ

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A loading phase of 1mg three times weekly for two weeks, then maintenance of 1mg every two to three months, adjusted for the cause and any neurological involvement

it contains a cyanide molecule attached to the core cobalamin ion