semaglutide/tirzepatide weight loss Medical Tirzepatide vs. Semaglutide: Key Differences

10.1210/er.2006-0007 51 GuirguisA.ChiappiniS.Papanti PG

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Cardiovascular Outcomes Trial of Semaglutide in Patients with Type 2 Diabetes Mellitus SUSTAIN 6 (NCT01720446) was a 104-week, double-blind trial in which 3,297 patients with type 2 diabetes and high risk of cardiovascular events were randomized to semaglutide 0.5 mg once weekly, semaglutide 1 mg once weekly, or placebo in addition to standard-of-care

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For example, nausea affects up to 44% of patients on the highest dose of semaglutide (Wegovy), though rates are typically lower at starting doses