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Tirzepatide reduces appetite through GIP and GLP-1 receptor activation in appetite-regulating brain centers, working through physiologic satiety pathways
The prevalence of MASLD is 60% to 70% among patients with T2DM (67)
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Emerging research suggests GLP-1 may also support cardiovascular health, healthy inflammatory responses, and normal nerve cell function
This is the patient group in which the STEP-HFpEF, STEP-HFpEF DM and SUMMIT trials demonstrated robust benefits
Jorjo AL, de Oliveira FE, Leo MV, Carvalho CA, Jorge AO, de Oliveira LD (2015) Live and heat-killed Lactobacillus rhamnosus ATCC 7469 may induce modulatory cytokines profiles on macrophages RAW 264.7
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