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PMID: 35678309
Orlistat (Xenical/Alli) blocks fat absorption in the gut
This partial agonism is intrinsic to orforglipron's binding mode: as an allosteric agonist occupying a smaller binding pocket with fewer receptor contacts than peptide ligands, it stabilizes a receptor conformation that is somewhat less efficient at coupling to Gs proteins than the fully peptide-activated state
Moisture-sensitive residues Certain amino acids are hygroscopic, meaning they readily absorb moisture from the surrounding air
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