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6,9 These treatments range from siRNA knockdowns in mammalian tissue culture to targeted antibodies (biologics) specific for the IGF-1R

Additionally, cAMP and PKA phosphorylate ERK1/2, which controls genes involved in proliferative and anti-apoptotic processes, and activate several proteins, such as the mitogen activated protein kinase (MAPK) cascades [63]

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Skipping the dose escalation schedule represents a serious error that significantly increases the risk of gastrointestinal adverse effects

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