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Cellular distribution studies of the nitric oxide-generating antineoplastic prodrug O(2)-(2,4-dinitrophenyl)1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate formulated in Pluronic P123 micelles

Bone marrow test

In the normal rats, L-NAME reduced bleeding time (and induced thrombocytopenia and thereby, the NOS-blocker-prothrombotic effect), L-arginine prolonged bleeding time (thereby showing the NOS-substrate-antithrombotic effect) [2931]

Irritating a nerve Injected in the wrong spot, a needle can come close to a nerve and cause sharp pain, tingling, numbness or weakness

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