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Most other NCEs under investigation follow traditional therapeutic avenues explored for uterine fibroids, which signals limited innovation: there are three GnRH antagonists, including merigolix (Phase II), and a selective progesterone receptor antagonist, telapristone, currently investigated in a Phase II study as a vaginal insert (both also investigated for endometriosis-related pain)

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But it is unprecedented for drugs to be put on the pathway to widespread adoption in this manner instead of having to go through the more arduous and evidence-based FDA drug approval process, experts say

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IV administration has been used in rodent research but is rarely used by human self-experimenters due to sterility and safety requirements

McRae says GLP-1s can be especially helpful for women navigating hormonal changes