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As detailed above in retinal degeneration models, recent rodent studies demonstrate that EE housing activates protective pathways in the retina by preventing diabetes-induced VEGF overexpression, a hallmark of early retinal compromise, and by preserving BDNF levels while diminishing inflammation and oxidative damage (Dorfman et al., 2014)

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Representative examples of transformation and delivery strategies employed in horticultural genome editing are summarized in Table 1

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Safety and tolerability of the hexadecapeptide AOD9604 in humans

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