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It might sound minor, but the distinction between these forms is really important

3a) Consistent with a deleterious role for free iron in ASCVD, ApoE-/- mice exposed to chronic iron overload displayed exacerbated atherosclerosis likely secondary to VEC damage or death, which was attenuated by dietary iron restriction or iron chelation 62,63

This is the formidable biological barrier that traditional treatments struggle to overcome

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Your body produces this powerful molecule naturally

Under certain conditions, usually transient effects might pass a certain threshold and then become subject to very different dynamics