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Rights and permissions About this article Cite this article Junnila, R., List, E., Berryman, D

2001;131(4 Suppl):1359S-61S

Clinical trials show tirzepatide produces greater average weight loss (22.5% vs 14.9% of body weight [1] )

"It is unclear if [the data] is specific to one of the GLP-1 drugs, if it relates to a specific headache type, or if there are safety and tolerability concerns to watch for," said Jessica Ailani, MD, a professor of clinical neurology and director of the Georgetown Headache Center at MedStar Georgetown University Hospital

The most common side effects of semaglutide are gastrointestinal in nature, with nausea occurring in up to 44% of patients in Wegovy clinical trials

The key mechanisms involve: (1) enhancement of antioxidant defense systems via the activation of NRF2, GPX4, and SLC7A11