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Overall, these subgroup analyses did not reveal meaningful heterogeneity in associations by obesity status, indicating no evidence of effect modification by obesity ( Supplementary Figures 4 , 5 )

Possible reasons for bowel prep to work slower than expected include: Constipation before taking prep solution: Constipation is when someone experiences difficulty passing bowel movements, and chronic constipation can slow bowel function, impacting when prep solutions work

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The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

Analyst 1990