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Clinical trials show a dose-response relationship: higher semaglutide doses produce greater weight loss, with 2.4 mg weekly yielding approximately 22% body weight reduction versus 15% at 1.0 mg

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As additional FDA submissions and real-world studies emerge, further clarification of optimal dosing strategies and sustained efficacy will shape its role in future metabolic treatment protocols

Patted PG, Masareddy RS, Patil AS, Kanabargi RR, Bhat CT

Second, a Yale study in mice found GLP-1 receptor agonists reduce the liver enzyme Cyp2e1, resulting in higher blood alcohol levels from the same amount consumed

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