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491 The A deposition hypothesis suggests that the normal mechanism of A removal from the brain tissue of AD patients is disrupted, leading to the accumulation of toxic A in the brain tissue to form A plaques, 492 and when the accumulation reaches a certain level, it triggers a series of neurodegenerative processes, such as inflammation, oxidative stress, and the deposition of Tau proteins, 493 which ultimately leads to a series of clinical conditions of AD

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Former Washington state resident Michael Slocumb was sentenced to 14 years in prison for his role in a drug trafficking ring that sold fentanyl pills, methamphetamine, and heroin in the Puget Sound region

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