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One study found that after people took semaglutide for 20 weeks and then stopped, they gained back almost 7% of their body weight within a year
Its consistent chemical structure supports reproducible study designs in endocrine and metabolic research
True fat regain follows a predictable timeline based on discontinuation studies: 15-20% weight regain in months 1-3, another 20-30% in months 4-9, plateauing around 70-80% total regain by 12-18 months
Currently, there are no specific therapies available for SIM, a situation that may be attributed to several factors
Each has distinct pros and cons
In June 2025, the EMAs safety division, the Pharmacovigilance Risk Assessment Committee (PRAC), concluded a review of GLP-1 medication and its risk of patients developing NAION
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