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A 2022 study in Diabetes, Obesity and Metabolism showed that NNMTi treatment combined with reduced-calorie diet "promoted dramatic whole-body adiposity and weight loss in diet-induced obese mice, rapidly normalizing" weight parameters

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These liposomes act like human cell membranes and protect the molecule from breaking down in the digestive system

First, the biodistribution of the liposomal formulation was not directly assessed, limiting the ability to correlate regional biochemical effects with drug delivery efficiency

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