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If considered for the indication of obesity in HFrEF, caution and close monitoring are warranted.

doi: [Research Gate] Kamat, P

Large doses can also increase the likelihood of oxalate stones in the urinary tract in patients with a history of nephrolithiasis, hyperoxaluria, or oxalosis

Research-Observed Effects Studies in animal models have documented various research-observed responses including nausea, decreased appetite, and yawning behaviors, often linked to MC-4R activation pathways