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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis
The new class of drugs, originally developed to treat diabetes, has been shown to help people drop 15% to 20% of their excess weight enough to substantially improve health problems like diabetes and heart issues
Even more surprising: Much of the cardiovascular protection appears to happen even when weight loss is small, suggesting semaglutide works through additional heart-protective mechanisms like lowering inflammation and improving blood vessel health
The maximum approved dose may be different if retatrutide is licensed in the future
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