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Most evidence comes from pharmacology principles and small observational studies rather than randomized controlled trials
But when stomach contents move more slowly into the small intestine, there can be other consequences, including any other oral medications that someone takes staying in the stomach for longer than intended
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It's also typically administered only once or twice a week
For context on the GLP-1 medications themselves: in the head-to-head SURMOUNT-5 trial, tirzepatide produced a 20.2% average body weight reduction vs
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