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Vessel depletion The development of anti-angiogenic drugs was initiated by the hypothesis that starving tumors by blocking angiogenesis would slow tumor progression and improve patient survival [1]

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This led to the discovery of the short gene regulatory regions called antioxidant response elements (AREs) that are required for xenobiotic and oxidative stress-induced expression of phase II detoxification enzymes (Rushmore and Pickett, 1990

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