While they produce modest LDL cholesterol reductions of 2-10%, statins remain first-line therapy for patients requiring significant lipid lowering, and GLP-1 agents work best as complementary therapy alongside statins
The clinical efficacy of semaglutide and tirzepatide has led to these drugs being among the most commonly prescribed in the USA, with an estimated one in eight people having used a GLP1 receptor agonist medication 4
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For example, GLP-1s might stimulate GLP-1 receptors in skins fibroblasts, impairing their ability to protect themselves from oxidative damage and produce new collagen, a structural protein in skin, suggests a study review published in Endocrine
Insulin and Insulin Resistance