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Patients often exhibit structurally abnormal, swollen mitochondria with disrupted cristae, impaired mitochondrial recycling (a process called mitophagy), and chronically elevated levels of reactive oxygen species
These medications are generally recommended for individuals who are overweight or obese, especially if they have additional health risks like type 2 diabetes or metabolic syndrome
They have also been shown to have positive effects on body composition and glucose levels
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You've been doing this for 30 years, and I think one of the probably biggest changes that have happened over the time that you've been working on obesity is that we've come to see obesity as a chronic recurring disease
