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To determine if GLP-1R induces cAMP generation specifically at VAPB locations, we modified a fluorescence resonance energy transfer (FRET)-based system of biosensors targeted to endogenous proteins (FluoSTEPs) 25 , so that a FRET cAMP sensor would fully reconstitute only in the presence of the GFP 11 fragment fused to VAPB, resulting in functional biosensor assembly specifically at VAPB loci (Supplementary Fig

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Glutathione disulfide Glutathione disulfide ( GSSG ) is a disulfide derived from two glutathione molecules

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It means maintenance is becoming a real treatment phase, not an afterthought