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It is more likely that your healthcare provider will start you on antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)

however, clues are beginning to emerge

Early- and later-stage persistence with antiobesity medications: A retrospective cohort study

Two psychiatrists published a 2025 report documenting significant improvement in depression and anxiety symptoms in two patients who started tirzepatide: The first patient was a 36-year-old with major depressive disorder, generalized anxiety disorder, and binge-eating disorder

Metformin: historical overview

This side effect is almost always related to overuse rather than the ingredient itself