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However, a meta-analysis including 37 eligible randomized controlled trials failed to identify an association between GLP-1RAs and increased risk of overall cancer

Nature (2016) 534(7606):2137

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doi: 10.1111/dom.13024 108 NovikoffAO'BrienSLBerneckerMGrandlGKleinertMKnerrPJet al

Non-responders to tirzepatide may benefit from retatrutide's additional glucagon mechanism, but subgroup analyses of poor tirzepatide responders haven't been definitively published