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The medication works by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying, as described in the FDA-approved prescribing information

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The Morton 2018 meta-analysis identified 1.6 g/kg as the plateau for muscle gain in resistance-trained adults [9], and the Helms 2014 evidence-based guidance for adults in a calorie deficit recommends 2.3 to 3.1 g per kg of fat-free mass [10] that is per kg of FFM, not total bodyweight, so for a leaner athlete it lands above the 2.0 g/kg total-BW number

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