[1] The challenge historically has been oral delivery
First, the FAERS database is a self-reporting system with reporting randomness (e.g., existing selective, incomplete, inaccurate, untimely, and unverified reporting) and massive missing data (e.g., age and dosage)
231,284 Summary of the evidence Evidence for the use of incretin-based therapies in a CVD primary prevention cohort largely draws from trials involving people with type 2 diabetes
Beyond Weight Loss: Additional Health Benefits of GLP-1 Medications Enhancing Cardiovascular Health These medications help lower blood pressure and improve cholesterol levels, reducing the risk of heart disease
They Do Not Work Alone Although powerful and effective, weight loss medications do not work alone
doi: 10.1056/NEJMoa1411892