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When beta cells are lost in type 1 diabetes or gradually become inactive in type 2 diabetes, the two hormones they produceinsulin and amylinare also lost

Wang C, Li Q, Wang W, Guo L, Guo C, Sun Y, et al

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Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes

So it was definitely one of the drivers